News & Media

FcRn Blockade with SYNT001 for the Treatment of Pemphigus

Werth, VP, et al. Poster presented at International Investigative Dermatology Meeting; May 2018, Orlando, Florida.

SYNT001: A Humanized IgG4 Monoclonal Antibody that Disrupts the Interaction of FcRn & IgG for the Treatment of IgG-Mediated Autoimmune Diseases

Blumberg, et al. Poster presented at the American Society of Hematology Meeting; December 2017, Atlanta, Georgia.

FcRn: the neonatal Fc receptor comes of age

Roopenian DC, Akilesh S., Nat Rev Immunol 2007; 7:715-25

Dependence of antibody-mediated presentation of antigen on FcRn

Qiao SW et al, Proc Natl Acad Sci USA. 2008; 105:9337-42

Role of Fc Receptors as a Therapeutic Target

Masuda, A. et al, Inflamm Allergy Drug Targets 2009 Marchl 8(1): 80-86

Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells

Baker, K. et al, Proc Natl Acad Sci USA. 2011; 108:9927-32

Cross-presentation of IgG-containing immune complexes

Baker, K. et al, Cell Mol Life Sci. 2013 April; 70(8): 1319-1334

The role of FcRn in antigen presentation

Baker, K. et al, Front Immunl. 2014; 5:408

FcRn: The architect behind the immune and nonimmune functions of IgG and albumin

Pyzik, M. et al, J Immunol 2015; 194:4595-603

Regulation of immune responses by the neonatal Fc receptor and its therapeutic implications

Rath, T. et al, Front. Immunol. 05 January 2015

Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury

Pyzik, M. et al, Proc Natl Acad Sci USA. 2017 doi: 10. 1073/pnas.1618291114

Pemphigus Vulgaris: Approach to Treatment

Sinha, A. et al, Eur J Dermatol 2015; 25(2): 103-13

Pemphigus Vulgaris: An Evidence-Based Treatment Update

Zhao, C. et al, Drugs 2015; 75: 271-284

The relevance of the IgG subclass of autoantibodies for blister induction in autoimmune bullous skin diseases

Sitaru, C. et al, Arch Dermatol Res 2007; 299: 1-8

Warm antibody autoimmune hemolytic anemia

Kalfa, T. ASH Education Book, vol. 2016 no. 1 690-697

Treatment of autoimmune hemolytic anemias

Zanella, A. and Barcellini, W., haematologica, 2014; 99(10)

Warm autoimmune hemolytic anemia: Advances in pathophysiology and treatment

Michel, M. Presse Med. 2014; 43: e97-e104